Bloodroot was used by eastern American Indian tribes as a red dye, and also in the treatment of ulcers, skin conditions and as a blood purifier. For ulcers and other open lesions, it's typically used as a topical wash. The most impressive health benefits of bloodroot include its ability to prevent certain types of cancer, protect against infections, boost heart health, improve the appearance of the skin, speed healing and recovery, increase circulation and soothe the pain of a migraine.